0001408443 2026-05-12 2026-05-12 0001408443 1 2026-05-12 2026-05-12 0001408443 2 2026-05-12 2026-05-12 0001408443 3 2026-05-12 2026-05-12 0001408443 4 2026-05-12 2026-05-12 0001408443 5 2026-05-12 2026-05-12 iso4217:USD pure S-3 S-3 EX-FILING FEES 0001408443 Milestone Pharmaceuticals Inc. N/A N/A 0.0001381 0.0001381 0.0001381 0.0001381 S-3 Milestone Pharmaceuticals Inc. Equity Common Shares, no par value per share true Equity Preferred Shares, no par value per share true Debt Debt Securities true Other Warrants true false Unallocated (Universal) Shelf true 300000000.00 0.0001381 41430.00 300000000.00 41430.00 0.00 0.00 41430.00 1.a. Separate consideration may or may not be received for securities that are issuable upon the conversion or exercise of, or in exchange for, other securities offered hereby. 1.b. There are being registered hereunder such indeterminate number of common shares, such indeterminate number of shares of preferred shares, such indeterminate principal amount of debt securities and such indeterminate number of warrants to purchase common shares, preferred shares or debt securities as shall have an aggregate initial offering price not to exceed $300,000,000. If any debt securities are issued at an original issue discount, then the principal amount of such debt securities shall be in such greater amount as shall result in an aggregate initial offering price not to exceed $300,000,000, less the aggregate dollar amount of all securities previously issued hereunder. Any securities registered hereunder may be sold separately or in combination with other securities registered hereunder. The $300,000,000 of securities registered hereunder includes $100,000,000 of common shares that may be offered, issued and sold pursuant to that certain Controlled Equity OfferingSM, dated May 13, 2026 by and between the registrant and Cantor Fitzgerald & Co. The securities registered also include such indeterminate number of shares of common shares, preferred shares and amount of debt securities as may be issued upon conversion of or exchange for preferred shares or debt securities that provide for conversion or exchange, upon exercise of warrants or pursuant to the antidilution provisions of any such securities. In addition, pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), the shares being registered hereunder include such indeterminate number of common shares and preferred shares as may be issuable with respect to the shares being registered hereunder as a result of share splits, share dividends or similar transactions. 1.c. The proposed maximum aggregate offering price per class of security will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder and is not specified as to each class of security pursuant to Instruction 2.A.iii.b under the heading "Instructions to the Calculation of Filing Fee Tables and Related Disclosure" of Part II, Item 16, of Form S-3 under the Securities Act.