Document and Entity Information Document Type Document Quarterly Report Document Period End Date Document Transition Report Securities Act File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, City or Town Entity Address, State or Province Entity Address, Country Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Condensed Consolidated Balance Sheets Statement [Table] Statement Statement [Line Items] Statement Assets [Abstract] Assets Assets, Current [Abstract] Current assets Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Short-Term Investments, Total Short-term investments Short-term investments Accounts Receivable, after Allowance for Credit Loss, Current Accounts receivable, net Amount of license receivables, due within one year or the operating cycle, if longer. License Receivables, Current, Total License receivable Carrying amount due within one year of the balance sheet date (or one operating cycle, if longer) from tax authorities as of the balance sheet date representing research and development expenditures. Tax Credits Receivable, Research and Development Research and development tax credits receivable Prepaid Expense, Current Prepaid expenses Inventory, Net Inventory, net Total inventory Other Receivables, Net, Current Other receivables Total Assets, Current Total current assets Operating Lease, Right-of-Use Asset Operating lease right-of-use assets Property, Plant and Equipment, Net Property and equipment, net Assets Total assets Liabilities and Equity [Abstract] Liabilities, and Shareholders' Equity Liabilities [Abstract] Liabilities Liabilities, Current [Abstract] Current liabilities Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued liabilities Total Operating Lease, Liability, Current Operating lease liabilities Deferred Revenue, Current Deferred revenue Other Liabilities, Current Other current liabilities Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Operating lease liabilities, net of current portion Long-Term Debt Total Senior secured convertible notes Amount of obligation for royalty financing, classified as noncurrent. Royalty Financing Obligation, Noncurrent Ending balance Beginning balance Royalty financing obligation, long-term Other Liabilities, Noncurrent Other long-term liabilities Liabilities Total liabilities Equity, Attributable to Parent [Abstract] Shareholders' Equity Common Stock, Value, Issued Common shares, no par value, unlimited shares authorized, 117,794,417 shares issued and outstanding as of March 31, 2026, 106,236,344 shares issued and outstanding as of December 31, 2025 Warrants and Rights Outstanding Pre-funded warrants - 16,412,925 issued and outstanding as of March 31, 2026 and 16,412,925 as of December 31, 2025 Additional Paid in Capital Additional paid-in capital Retained Earnings (Accumulated Deficit) Accumulated deficit Equity, Attributable to Parent Ending balance Beginning balance Total shareholders' equity Liabilities and Equity Total liabilities and shareholders' equity Common Stock, Par or Stated Value Per Share Common shares, par value (in dollars per share) Common Stock, Shares Authorized, Unlimited [Fixed List] Common shares, Shares authorized (in shares) Common Stock, Shares, Issued Common shares, Shares issued (in shares) Common Stock, Shares, Outstanding Ending Balance (in shares) Beginning Balance (in shares) Common shares, Shares outstanding (in shares) Number of warrants or rights issued. Class Of Warrant Or Right Issued Pre-funded warrants, Warrants issued (in shares) Class of Warrant or Right, Outstanding Ending Balance, warrants (in shares) Beginning Balance, warrants (in shares) Pre-funded warrants, Warrants outstanding (in shares) Warrants outstanding Condensed Consolidated Statements of Loss Revenue from Contract with Customer, Excluding Assessed Tax Product revenue, net Product revenues Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer License revenue License and other revenue Revenues Revenue Total revenues Operating Expenses [Abstract] Operating Expenses Less: Cost of Product and Service Sold Cost of product sales Research and Development Expense Research and development, net of tax credits Research and development, net of tax credits, excluding share-based compensation General and Administrative Expense General and administrative General and administrative, excluding share-based compensation Expenses recognized in the period that are directly related to the commercial of products or services. Commercial Expense Commercial Commercial, excluding share-based compensation Costs and Expenses Total operating expenses Operating Income (Loss) Loss from operations Investment Income, Interest Interest income Interest income Interest Expense, Nonoperating Interest expense Note payable interest expense Net loss and comprehensive loss Net loss Number of basic shares or units and pre-funded warrants, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time. Weighted Average Number Of Shares And Prefunded Warrants Outstanding Basic Weighted average number of shares and pre-funded warrants outstanding, basic (in shares) Number of diluted shares or units and pre-funded warrants, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time. Weighted Average Number Of Shares And Prefunded Warrants Outstanding Diluted Weighted average number of shares and pre-funded warrants outstanding, diluted (in shares) Earnings Per Share, Basic Net loss per share, basic (in dollars per share) Earnings Per Share, Diluted Net loss per share, diluted (in dollars per share) Condensed Consolidated Statements of Shareholders' Equity Equity Components [Axis] Equity Component [Domain] Common Stock [Member] Common Shares Represents the information pertaining to pre funded warrants. Pre Funded Warrant [Member] Pre-funded warrants Additional Paid-in Capital [Member] Additional paid-in capital Retained Earnings [Member] Accumulated deficit Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Represents information relating to Series A common warrants. SeriesA Common Warrants [Member] Series A common warrants Series A common stock warrants n/a Increase (Decrease) in Stockholders' Equity and Temporary Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Share-based compensation Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Issuance of common shares, vesting of restricted stock units Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture Number of shares issued upon exercise of options Issuance of common shares, vesting of restricted stock units (in shares) Stock Issued During Period, Value, New Issues Issuance of common shares, net of issuance costs Stock Issued During Period, Shares, New Issues Number of shares issued during the period Issuance of common shares, net of issuance costs (in shares) Value of stock issued upon exercise of warrants. Stock Issued During Period, Value, Warrants Exercised Exercise of Series A common stock warrants, net of issuance costs Shares of stock issued as a result of the exercise of warrants. Stock Issued During Period, Shares, Warrants Exercised Exercise of Series A common stock warrants, net of issuance costs (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Employee stock purchase plan purchases Stock Issued During Period, Shares, Employee Stock Purchase Plans Employee stock purchase plan purchases (in shares) Condensed Consolidated Statements of Cash Flows Net Cash Provided by (Used in) Operating Activities [Abstract] Cash flows used in operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Depletion and Amortization Depreciation of property and equipment Amortization of Debt Issuance Costs and Discounts Amortization of debt costs Amount recognized for accretion or amortization of investment discount or premium. Accretion Amortization Expense Of Investment Discount Or Premium Accretion of investment discount Paid-in-Kind Interest Non-cash interest expense related to senior secured convertible note Interest paid other than in cash for royalty financing obligations. Paid in Kind Interest for Royalty Financing Obligation Non-cash interest expense related to royalty financing obligation Share-Based Payment Arrangement, Noncash Expense Share-based compensation expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable, net Increase (Decrease) in Other Receivables Other receivables Amount of increase (decrease) in receivables classified as research and development tax credits receivable. Increase (Decrease) in Research and Development Tax Credits Receivable Research and development tax credits receivable Increase (Decrease) in Prepaid Expense Prepaid expenses Increase (Decrease) in Inventories Inventory The amount of increase (decrease) in operating lease right of use asset, net. Increase Decrease In Operating Lease Right Of Use Asset, Net Operating lease assets and liabilities Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued liabilities Increase (Decrease) in Deferred Revenue Deferred revenue Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities [Abstract] Cash flows provided by (used in) investing activities Payments to Acquire Property, Plant, and Equipment Acquisition of property and equipment Payments to Acquire Short-Term Investments Acquisition of short-term investments Proceeds from Sale, Maturity and Collection of Short-Term Investments Redemption of short-term investments Net Cash Provided by (Used in) Investing Activities Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Cash flows provided by (used in) financing activities The cash inflow from royalty financing arrangement. Proceeds From Royalty Financing Arrangement Proceeds from Royalty Financing Arrangement Purchase price received Proceeds from Issuance of Common Stock Proceeds from issuance of common shares, net of issuance costs Proceeds from Warrant Exercises Proceeds from exercise of series A warrants, net of issuance costs Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Excluding Option Exercised Proceeds from employee stock purchase plan Amount of cash outflow related to payments for property and equipment financing. Payments Of Property And Equipment Financing Payment of property and equipment financing Net Cash Provided by (Used in) Financing Activities Cash provided by financing activities Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net (decrease) increase in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash and cash equivalents - End of period Cash and cash equivalents - Beginning of period Organization and Nature of Operations Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Organization and Nature of Operations Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Revenues. Revenue from Contract with Customer [Text Block] Revenues Short-term Investments Investments and Other Noncurrent Assets [Text Block] Short-term Investments Inventory Inventory Disclosure [Text Block] Inventory Debt Debt Disclosure [Text Block] Debt Accrued Liabilities The entire disclosure for accrued liabilities at the end of the reporting period. Accrued Liabilities Disclosure [Text Block] Accrued Liabilities Shareholders' Equity Equity [Text Block] Shareholders' Equity Share-Based Compensation Compensation and Employee Benefit Plans [Text Block] Share-Based Compensation Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share n/a. Royalty Financing Obligation The disclosure of information pertaining to purchase and sale agreement during the period of an entity. Royalty Purchase Agreement [Text Block] Royalty Financing Obligation Other Receivables The entire disclosure for other receivables. Other Receivables [Text Block] Other Receivables Segment Reporting Segment Reporting Disclosure [Text Block] Segment Reporting Fair value of financial instruments Fair Value Disclosures [Text Block] Fair value of financial instruments Subsequent Event Subsequent Events [Text Block] Subsequent Event Consolidation, Policy [Policy Text Block] Basis of Consolidation Basis of Presentation and Significant Accounting Policies [Text Block] Basis of Presentation and Use of Accounting Estimates and Significant Accounting Policies Disclosure of accounting policy related to significant risks and uncertainties. Significant Risks and Uncertainties Policy [Policy Text Block] Significant Risks and Uncertainties New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Disclosure of accounting policy for sources of liquidity and funding requirements. Sources of Liquidity and Funding Requirements Policy [Policy Text Block] Sources of Liquidity and Funding Requirements Revenue [Policy Text Block] Revenue Recognition Cost of Goods and Service [Policy Text Block] Cost of Product Sales Disclosure of accounting policy for royalty financing obligation. Royalty Financing Obligation, Policy [Policy Text Block] Royalty Financing Obligation Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Risks Inventory Supplies, Policy [Policy Text Block] Inventory Income Tax, Policy [Policy Text Block] Income Taxes Schedule of Inventory, Current [Table Text Block] Schedule of inventory Convertible Debt [Table Text Block] Schedule of convertible notes Tabular disclosure of interest cost on debt instrument. Schedule Of Interest Cost On Debt [Table Text block] Schedule of total amount of interest cost Schedule of Accrued Liabilities [Table Text Block] Schedule of accrued liabilities Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block] Schedule of outstanding and exercisable options Schedule of Nonvested Share Activity [Table Text Block] Schedule of non-vested share options activity Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of weighted average assumptions for the options granted Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Schedule of restricted stock units Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Schedule of share-based compensation expense Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of potentially dilutive securities excluded from the computation of diluted weighted average shares Tabular disclosure of activity pertaining to royalty financing obligation. Schedule of Royalty Financing Obligation [Table Text Block] Schedule of royalty financing obligation activity The tabular disclosure for other receivables. Schedule Of Other Receivables Table Text Block Schedule of other receivables Schedule of Segment Reporting Information, by Segment [Table Text Block] Schedule of segment significant expenses Class of Warrant or Right [Table] Class of Warrant or Right [Line Items] Class of Warrant or Right Cash, Cash Equivalents, and Short-Term Investments Cash, cash equivalents and short-term investments The number of milestones. Number Of Milestones Number of milestones Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Revenues Investment Income [Table] Statistical Measurement [Axis] Statistical Measurement [Domain] Minimum [Member] Minimum Maximum [Member] Maximum Net Investment Income [Line Items] Net Investment Income Investment Interest Rate Interest rate earned from short-term investments Debt Instrument, Collateral Amount Pledged collateral Inventory, Work in Process, Net of Reserves Work-in-process Inventory, Finished Goods, Net of Reserves Finished goods Schedule of Long-Term Debt Instruments [Table] Counterparty Name [Axis] Counterparty Name [Domain] Represents information pertaining to RTW Investments LP. Rtw Investments Lp [Member] RTW Investments, LP Long-Term Debt, Type [Axis] Long-Term Debt, Type [Domain] Convertible Debt [Member] Senior Secured Convertible Notes Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Represents information pertaining to strategic financing agreements. Strategic Financing Agreements [Member] Strategic Financing Agreements Debt Instrument [Line Items] Debt Instruments Proceeds from Convertible Debt Proceeds from convertible notes Coupon rate, under the debt agreement. Debt Instrument, Coupon Rate Percentage Coupon rate (as a percent) Convertible Debt, Fair Value Disclosures Estimated Fair Value Long-Term Debt, Gross Original principal Amount of paid-in kind interest payable on debt. Debt Instrument, Paid in Kind Interest Payable Paid in kind (PIK) interest Debt Instrument, Unamortized Discount Unamortized debt discount Debt Issuance Costs, Net Unamortized debt issuance costs Interest Expense, Debt, Excluding Amortization Contractual interest expense Amortization of Debt Discount (Premium) Amortization of debt discount Amortization of Debt Issuance Costs Amortization of debt issuance costs Interest Expense, Debt Total Employee-related Liabilities, Current Accrued compensation and benefits payable Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Research and Development Liabilities, Current Accrued research and development liabilities Carrying value as of the balance sheet date of obligations incurred through that date and payable accrued for commercial liabilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Commercial Liabilities, Current Accrued commercial liabilities Carrying value as of the balance sheet date of an underwriting fee that has been incurred but not yet paid. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Underwriting Fees, Current Accrued underwriting fees Underwriting commissions payable Accrued Professional Fees, Current Accrued legal liabilities Other Accrued Liabilities, Current Other accrued liabilities Amount of revenue related reserves for discounts and allowances. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Revenue Related Reserves For Discounts And Allowances, Current Revenue-related reserves for discounts and allowances Stock, Class of Stock [Table] Sale of Stock [Axis] Sale of Stock [Domain] Employee Stock [Member] Employee Stock Purchase Plan Class of Stock [Line Items] Authorized share capital Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Number of common shares available for issuance Common Stock, Capital Shares Reserved for Future Issuance Shares reserved for issuance Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized Additional shares reserved for issuance Represents information relating to Series B common warrants. SeriesB Common Warrants [Member] Series B common warrants Represents information relating to Pre-funded warrant Series A common warrants. Pre Funded Warrant, SeriesA Common Warrants [Member] Pre funded warrant and series A common warrants Represents information relating to Pre-funded warrant Series B common warrants. Pre Funded Warrant, Series B Common Warrants [Member] Pre funded warrant and series B common warrants Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants issued to purchase shares Per share or per unit amount of warrants issued. Warrants, Offering Price Warrants offering price Class of Warrant or Right, Exercise Price of Warrants or Rights Warrants exercise price Shares Issued, Price Per Share Public offering price Proceeds from Issuance or Sale of Equity Proceeds from issuance or sale of equity Payments of Stock Issuance Costs Stock issuance cost Payment of underwriting commissions and other offering expenses Represents information pertaining to at the market offering. At Market Offering [Member] ATM Program The net cash inflow associated with the amount received from holders exercising their stock warrants. Amount net of underwriting commissions. Proceeds from Warrant Exercises, Net Proceeds from exercise of warrants, net of issuance costs Payments for Underwriting Expense Underwriting commissions Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Plan Name [Axis] Plan Name [Domain] Represents information pertaining to restated 2011 stock option plan. Restated Share Option Plan 2011 [Member] 2011 Plan Represents the information pertaining to 2019 Equity Incentive Plan. Equity Incentive Plan 2019 [Member] 2019 Plan Represents the information pertaining to inducement plan. Inducement Plan [Member] Inducement Plan Vesting [Axis] Vesting [Domain] Share-Based Payment Arrangement, Tranche One [Member] Share-based Compensation Award, Tranche One Share-Based Payment Arrangement, Tranche Two [Member] Share-based Compensation Award, Tranche Two Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share-based compensation Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage Percentage of shares to vest Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Vesting period Represents the number of options forfeited after termination of one plan became available in 2019 plan. Share-based Compensation Arrangement by Share-based Payment Award, Options Forfeited, Became Available For Issuance Number of options forfeited after termination of one plan The number of shares under options that were cancelled during the reporting period pertaining to the stock option plan. Share-based Compensation Arrangement by Share-based Payment Award, Options Cancelled, Number of Shares Cancelled Cancelled Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Shares available for future grants Represents information for 2011 Plan, 2019 Plan and 2021 Inducement Plans. Plans 2011 and 2019 and 2021 Inducement [Member] Plans 2011 and 2019 and 2021 Inducement Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Outstanding and exercisable options, number of shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Outstanding at end of year Outstanding at beginning of year Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Granted Options granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Exercisable at end of year Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Outstanding and exercisable options, weighted average exercise price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Outstanding at end of year Outstanding at beginning of year Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Exercisable at end of year Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Weighted average remaining contractual life (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term Weighted average remaining contractual life for vested options (in years) Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Unrecognized compensation cost Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Expected period for recognition Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares [Roll Forward] Number of options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares Non-vested share options at end of year Non-vested at beginning of year Gross number of share options (or share units) granted during the period that are nonvested. Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross, Nonvested Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares Vested, outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted average fair value Share-Based Compensation Arrangement by Share-Based Payment Award, Option, Nonvested, Weighted Average Exercise Price Non-vested at end of year Non-vested at beginning of year Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Granted Weighted average fair values of options granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value Vested, outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price Exercise price (in dollars per share) Strike price (in dollars per share) It represents information pertaining to fair value of exercise price Sharebased compensation arrangement by sharebased payment award grants in period weighted average fair value exercise price Exercise price Weighted-average fair value price paid per share during the reporting period for shares purchased on open market for issuance under share-based payment arrangement. Share-based Compensation Arrangement by Share-based Payment Award, Weighted Average Fair Value Price Per Share Share price (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Volatility (as a percent) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Risk-free interest rate (as a percent) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Expected life (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Dividend (as a percent) Grant date fair value of options under share-based payment arrangement. Share-Based Compensation Arrangement by Share-Based Payment Award, Grant Date Fair Value Original grant-date fair value Share-based payment option arrangement awarded for meeting performance target. Performance Stock Options [Member] Performance Stock Options Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Expiration term (in years) Share-Based Payment Arrangement, Expense Share-based compensation expense Represents the information pertaining to employee stock purchase plan. Employee Stock Purchase Plan [Member] ESPP The percentage of wages eligible employees may authorize of their salary to purchase common stock. Percentage of Wages Eligible Employees Authorize To Purchase Common Stock Percentage of wages eligible employees may authorize of their salary to purchase common stock The percentage of discount at which an eligible employee may purchase common stock of each purchase interval. Share Based Compensation Arrangement By Share Based Payment Award Employee Stock Purchase Plan Market Discount At Beginning Or Ending Purchase Interval Percentage of discount at which an eligible employee may purchase common stock of each purchase interval The duration of of each purchase interval expressed as in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Share Based Compensation Arrangement By Share Based Payment Award Employee Stock Purchase Plan Market Interval Term Duration of of each purchase interval The automatic reset period. Share Based Compensation Arrangement By Share Based Payment Award Employee Stock Purchase Plan Reset Term Automatic reset period The number of shares issued under Employee Stock Purchase Plan. Employee Stock Purchase Plan, Number Of Shares Issued Number of shares issued Performance Shares [Member] Performance Share Units Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Granted Award granted Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value Granted Restricted Stock Units (RSUs) [Member] Restricted Stock Units Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Number of shares Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Outstanding at end of period Outstanding at beginning of period Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted average exercise price Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Outstanding at end of period Outstanding at beginning of period Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Vested Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount Unrecognized compensation Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Statement of Income Location, Balance [Axis] Statement of Income Location, Balance [Domain] General and Administrative Expense [Member] Administration Research and Development Expense [Member] Research and development Primary financial statement caption in which the reported facts about commercial activities have been included. Commercial Activities [Member] Commercial activities Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Share-based compensation Antidilutive Security, Excluded EPS Calculation [Table] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Share-Based Payment Arrangement [Member] Share options Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net Loss Per Share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Stock options and RSUs Discloses pertinent information about the royalty purchase agreement Royalty Purchase Agreement [Table] Scenario [Axis] Scenario [Domain] Represents information pertaining to annual aggregate net sales up to 500 million. Aggregate Net Sales Up to 500 Million [Member] Up to $500 million Represents information pertaining to annual aggregate net sales above 500 million. Aggregate Net Sales Above 500 Million [Member] Above $500 million Represents information pertaining to annual aggregate net sales up to 800 million. Aggregate Net Sales Up to 800 Million [Member] Up to $800 million Represents information pertaining to annual aggregate net sales above 800 million. Aggregate Net Sales Above 800 Million [Member] Above $800 million Information about the royalty purchase agreement Royalty Purchase Agreement [Line Items] Royalty Financing Obligation Amount of funding received from the sale of product rights. Funding Received Upon Sale Of Product Rights Funding received from sale of product rights The future payments on product sales as percent of aggregate net sales. Future Payments on Product Sales, as Percent of Aggregate Net Sales Future payment as a percentage of aggregate net sales The threshold amount of annual aggregate net sales for future payments calculation. Threshold Annual Aggregate Net Sales for Future Payments Calculation Threshold amount of annual aggregate net sales The additional future payments on product sales as percent of aggregate net sales. Additional Future Payments on Product Sales, as Percent of Aggregate Net Sales Additional future payment as a percentage of aggregate net sales A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period. Royalty Financing Obligation [Roll Forward] Royalty Financing Obligation [Roll Forward] Amount of decrease in the royalty financing obligation for full or partial settlement through consideration other than cash. Royalty Financing Obligation, Settled Without Cash Royalty financing interest expense Non-cash Interest expense on Royalty financing obligation Amount of increase (decrease) in the royalty financing obligation through paid and payables. Royalty Financing Obligation, Royalty Paid And Payable Royalty revenues paid and payable Effective interest rate for the royalty financing obligations. Royalty Financing Obligation, Effective Interest Rate Effective Interest Interest Receivable, Current Interest receivable Value Added Tax Receivable, Current Sales tax receivable Carrying amount as of the balance sheet date of Employee withholding taxes receivable. For classified balance sheets, represents the current amount receivable, that is amounts expected to be collected within one year or the normal operating cycle, if longer. Employee Withholding Taxes Receivable, Current Employee withholding taxes receivable Amount of other current receivable. Other Current Receivable Other current receivable Schedule of Revenue by Major Customers, by Reporting Segments [Table] Segments [Axis] Segments [Domain] Represents the single segment of the Company. Single Reportable Segment [Member] Single reporting Revenue, Major Customer [Line Items] Segment information Number of Operating Segments Number of operating segments Number of Reportable Segments Number of reportable segments Fair Value, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Measurement Frequency [Domain] Fair Value, Recurring [Member] Recurring Fair Value, Nonrecurring [Member] Non-recurring Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis Assets, Fair Value Disclosure Fair value of financial instruments Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent event Subsequent Event [Line Items] Subsequent Event Number of warrants exercised during the period. Number Of Warrants Exercised Number of warrants exercised Sales commission percentage. Sales Agent Commission, Percent Sales commission percentage n/a Rule 10b5-1 Arrangement Modified n/a Non-Rule 10b5-1 Arrangement Modified